Antibodies are useful vehicles for carrying small molecule drugs to their therapeutic targets. Finding the appropriate drug to antibody-ratio (DAR) is crucial for the right balance between therapeutic efficacy and toxicity. Today’s application note shows the use of SEC-MS to analyze the DAR of an antibody-drug conjugate (ADC) mimic. HIC-UV is used as orthogonal method confirming the obtained results. Antibodies are useful vehicles for carrying small molecule drugs to their therapeutic targets. Finding the appropriate drug to antibody-ratio (DAR) is crucial for the right balance between therapeutic efficacy and toxicity. Today’s application note shows the use of SEC-MS to analyze the DAR of an antibody-drug conjugate (ADC) mimic. HIC-UV is used as orthogonal method confirming the obtained results.
Click photo below to download the PDF-file with more information.
Columns used:
| TSKgel SuperSW3000, 4 µm, 2.0 mm ID x 30 cm L (PN 0021485) |
| TSKgel Butyl-NPR, 2,5 µm, 4,6 mm ID x 10 cm L (PN 0042168) |
For further information about the columns, please contact
MD Scientific – info@md-scientific.dk – +45 7027 8565 – or at http://www.md-scientific.dk
